吴海珍

生物学专业：博士生导师/硕士生导师

生物工程专业：博士生导师/硕士生导师

生物与医药专业（生物工程领域）：博士生导师/硕士生导师

1975年生，2000年获我校生物化学与分子生物学硕士学位，2005年获我校生物化工博士学位。2016年升教授，现任应用生物学系主任。

研究方向：合成生物学及生物智造，擅长代谢与信号途径的基因遗传操作。

近三年来发表的论文

（1）Ruida Wang, Tianyu Zhou, Fanjing Kong, Bingbing Hou, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis. Applied Microbiology of Biotechnology. 2023. doi: 10.1007/s00253-023-12429-z

（2）Kang Yajing, Wu Wei, Zhang Feixue, Chen Lei, Wang Ruida, Ye Jiang*, Wu Haizhen*, Zhang Huizhan. AdpAlin regulates lincomycin and melanin biosynthesis by modulating precursors flux in Streptomyces lincolnensis. J Basic Microbiol. 2023. doi: 10.1002/jobm.202200692.

（3）Bingbing Tu, Yue Mao, Ruida Wang, Yajing Kang, Jiang Ye, Huizhan Zhang , Haizhen Wu*. An alternative σ factor σL sl regulates lincomycin production in Streptomyces lincolnensis. Journal of Basic Microbiology. 2022. doi: 10.1002/jobm.202200485.

（4）Ruida Wang, Yuan Cao, Fanjing Kong, Bingbing Hou, Jiaqi Zhao, Yajing Kang, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. Developmental regulator RamR sl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis. Journal of Applied Microbiology. 2022. doi: 10.1111/jam.15568.

（5）Bingbing Hou, Ruida Wang, Jingyun Zou, Feixue Zhang, Haizhen Wu*, Jiang Ye*, Huizhan Zhang. A putative redox-sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensis. Journal of Basic Microbiology. 2021. 61(9):772-781. doi: 10.1002/jobm.202100249.

（6）Bingbing Hou, Xichen Yang, Hui Xia, Haizhen Wu*, Jiang Ye, Huizhan Zhang*. sRNA EsrE is transcriptionally regulated by the ferric uptake regulator Fur in Escherichia coli. Journal of Microbiology and Biotechnology. 2020, 30(1): 127-135, doi: 10.4014/jmb.1907.07026.

（7）Ke Ma, Siwei Chen, Yue Wu, Yiting Ma, Haochen Qiao, Jianhua Fan^*, Haizhen Wu^*. Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology. 2022. 106(2):773-788. DOI: 10.1007/s00253-021-11751-8.

（8）Ke Ma, Lei Deng, Jianhua Fan*, Haizhen Wu*.Towards green biomanufacturing of high-value recombinant proteins using promising cell factory: Chlamydomonas reinhardtii chloroplast. Bioresources and Bioprocessing. 2022. 9:83.

（9）Jianhua Fan*, Qiuwen Bao, Ke Ma, Xiaofei Li, Jing Jia, Haizhen Wu*. Antioxidant and innate immunity of Danio rerio against Edwardsiella tarda in response to diets including three kinds of marine microalgae. Algal Research, 2022, 64, 102689.

（10）Ke Ma, Qiuwen Bao, Yue Wu, Siwei Chen, Shunxin Zhao, Haizhen Wu*, Jianhua Fan*. Evaluation of microalgae as immunostimulants and recombinant vaccines for diseases prevention and control in aquacture. Frontiers in Bioengineering and Biotechnology. 2020. 8:590431. doi: 10.3389/fbioe.2020.590431

联系方式

上海市梅陇路130号365信箱，实验十四楼辅楼（小白楼）二楼；

电话：021-64252507；E-mail：wuhzh@ecust.edu.cn